What is this medication?
Antidepressant, Serotonin/Norepinephrine Reuptake Inhibitor
Duloxetine/Cymbalta/Drizalma is officially indicated for fibromyalgia, generalized anxiety disorder, major depressive disorder, chronic musculoskeletal pain, and diabetic neuropathy. It is also prescribed off-label for chemotherapy induced peripheral neuropathy and stress urinary incontinence. (may be used for conditions not listed)
“ALERT: US Boxed Warning
Suicidal thoughts and behavior:
Antidepressants increased the risk of suicidal thoughts and behavior in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening, and for emergence of suicidal thoughts and behaviors.”
How does this medication work?
Duloxetine/Cymbalta/Drizalma is a strong inhibitor of serotonin and norepinephrine reuptake and a weak inhibitor of dopamine reuptake within the neuron. It does not affect muscarinic, histamine 1, or alpha 2 adrenergic receptors or MAO.
How should I take this medication?
Oral: 30-120mg once daily
How to Take: Follow instructions provided by physician/pharmacy label, swallow whole, take consistently at same time each day unless otherwise directed, store at room temperature.
You Need to Avoid: This medication can increase the psychomotor impairment from alcohol consumption so extra care should be taken if choosing to consume alcohol. Do not stop this medication without tapering dose down over time to prevent withdrawal symptoms (nausea, diarrhea, sweating, headaches, agitation, insomnia, anxiety, tremor, vertigo, dizziness).
What should I watch for while using this medication?
Before starting Duloxetine/Cymbalta/Drizalma make sure your physician is aware of any allergies or medications you currently take, if you have liver disease, gastroparesis, if you have bipolar disorder, kidney disease, a seizure disorder, cardiovascular disease, or are pregnant or breastfeeding. This medication has risk of causing serotonin syndrome especially if combined with other serotonergic drugs. It can cause suicidal ideation, usually in young patients, with major depressive disorder so must be used with caution and any major changes in personality or mood should be reported to physician immediately.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Headache, drowsiness, fatigue, nausea, xerostomia (dry mouth), abdominal pain, weight loss, weakness, insomnia, dizziness, constipation, diarrhea
Note this is not a complete list of side effects, only common ones
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