COTELLIC (Cobimetinib)

COTELLIC (Cobimetinib)

Vendor
HOFFMAN-LA ROCHE
Regular price
$8,499.99 USD
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$8,499.99 USD
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Shipped from Canada.

prescription

What is this medication?

Cobimetinib, Cotellic
Antineoplast Agent, MEK Inhibitor

How does this medication work? 

Cobimetinib, Cotellic is a potent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway which regulates the extracellular signal-related kinase (ERK) pathway. The ERK pathway promotes cellular proliferation.  Cobimetinib, Cotellic has been shown to increase apoptosis and reduce overall tumor growth.

How should I take this medication? 

Oral: 60mg once daily from days 1 to 21 of each 28-day treatment cycle.

Take with or without food.  Swallow whole; do not crush, cut or chew the tablet.

What should I watch for while using this medication? 

Before starting Cobimetinib, Cotellic make sure your physician is aware of any allergies or medications you currently take.  Cobimetinib, Cotellic has been associated with a number of serious adverse effects such as cardiomyopathy, dermatologic toxicity, hemorrhage, hepatotoxicity, hypertension, cutaneous malignancies, ophthalmic effects and rhabdomyolysis.

What if I miss a dose?

If a dose is missed or if vomiting occurs after a dose is taken, resume with the next scheduled dose (do not take an additional dose).

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Reduction in ventricular ejection fraction, hypertension, photosensitivity, acneiform eruption, elevated liver enzymes, electrolyte disturbances, diarrhea, nausea, vomiting, stomatitis, hematologic disturbances (i.e. lymphocytopenia, anemia, thrombocytopenia, hemorrhage, ecchymoses, epistaxis, gingival hemorrhage, hematemesis, visual impairment, retinal detachment, fever, chills, skin rash, keratoacanthoma, squamous cell carcinoma of the skin and gastrointestinal and genitourinary hemorrhage.

Note this is not a complete list of side effects for Cobimetinib, Cotellic only common ones.