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What is this medication?

Colchicine, Colcrys
Antigout Agent

Colchicine/Colcrys is officially indicated for gout flares or treatment or familiar Mediterranean fever.  It is also prescribed off-label for Behcet syndrome, calcium pyrophosphate crystal arthritis, pericarditis, post pericardiotomy syndrome prevention, acute febrile neutrophilic dermatosis, cutaneous small-vessel vasculitis. (may be used for conditions not listed)

How does this medication work? 

Colchicine/Colcrys alters cell cytoskeleton by inhibiting microtube formation thereby inhibiting neutrophil functions associated with mediating gout symptoms.  It may also interfere with the intracellular assembly of the inflammasome complex in neutrophils and monocytes in familial Mediterranean fever.

How should I take this medication? 

Oral: 0.6-3mg daily divided into 1-3 doses depending on the condition it is used for and patient tolerance to side effects.  There are many regimens involving loading dosages and maintenance dosages, or even with multiple days between dosages all with the intent of using the lowest effective amount of colchicine for the shortest period of time due to its narrow therapeutic index and risk of side effects. 

How to Take: Follow instructions provided by physician/pharmacy label, take consistently at same times each day unless otherwise directed, store at room temperature  

What should I watch for while using this medication? 

Before starting Colchicine/Colcrys make sure your physician is aware of any allergies, medications you currently take, liver disease, kidney disease, or are pregnant or breastfeeding. 

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Gastrointestinal effects including diarrhea, vomiting, and nausea

Note this is not a complete list of side effects, only common ones.