What is this medication?
Antineoplastic Agent, Tyrosine Kinase Inhibitor
Chronic lymphocytic leukemia or small lymphocytic lymphoma, Mantle cell lymphoma (previously treated)
How does this medication work?
Acalabrutinib, Calquence is a selective inhibitor of Bruton’s tyrosine kinase (BTK) which signals activation of the pathways required for the growth and multiplication of cancerous B-cells and overall tumor growth.
How should I take this medication?
Oral: 100mg every 12 hours.
How to Take: Can take with or without food, at least 12 hours apart between successive doses. Swallow the capsule whole with water; do not open, break or chew capsules. Never taken with proton pump inhibitors and make sure to separate from H2 antagonists and antiacids by at least 2 hours apart.
What should I watch for while using this medication?
Before starting Acalabrutinib, Calquence make sure your physician is aware of any allergies or medications you currently take. You should be aware that Acalabrutinib, Calquence can cause bone marrow suppression resulting in neutropenia, thrombocytopenia and lymphopenia. A small number of patients have experienced atrial flutter while taking Acalabrutinib, Calquence. Monitor for signs of GI toxicity (i.e. diarrhea, nausea, vomiting); hemorrhage and infections.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Headache, fatigue, skin rash, diarrhea, nausea, abdominal pain, constipation, vomiting, neutropenia, anemia, malignant neoplasm, muscle pain.
Note this is not a complete list of side effects, only common ones.
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