What is this medication?
Antineoplastic Agent, Tyrosine Kinase Inhibitor, Vascular Endothelial Growth Factor (VEGF) Inhibitor
Cabozantinib, Cabometyx/Cometriq is indicated for treatment of hepatocellular carcinoma, renal cell carcinoma, and thyroid cancer.
How does this medication work?
Cabozantinib, Cabometyx/Cometriq is a tyrosine kinase inhibitor that inhibits multiple receptor kinases, including vascular endothelial growth factor (VEGF) inducing apoptosis of cancer cells and suppressing tumor growth, angiogenesis and metastasis.
How should I take this medication?
Oral: 60mg to 140mg once daily depending upon type of carcinoma.
How to Take: Take on an empty stomach (1 hour before or 2 hours after meals). Swallow whole; do not open capsules or crush tablets.
What should I watch for while using this medication?
Before starting Cabozantinib, Cabometyx/Cometriq make sure your physician is aware of any allergies or medications you currently take. Cabozantinib, Cabometyx/Cometriq has been shown to cause dermatologic toxicity (i.e. palmar-plantar erythrodysesthesia syndrome), gastrointestinal toxicity (i.e. diarrhea, vomiting, perforations and fistulas), hemorrhage, hypertension, osteonecrosis of the jaw, proteinuria, and thromboembolic events (i.e. pulmonary embolism, arterial or venous thromboembolic events) all of which require medical intervention.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. Do not take a missed dose within 12 hours of the next dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Hypertension, alopecia, erythema of the skin, hair discoloration, skin rash, xeroderma, hyperglycemia, hypoalbuminemia, electrolyte disturbances (i.e. hypocalcemia, hypokalemia, hypomagnesmia, hyponatremia), elevated liver enzymes, weight loss, constipation, diarrhea, dysgeusia, dyspepsia, stomatitis, vomiting, proteinuria, hematologic disturbances (i.e. anemia, leukopenia, neutropenia, thrombocytopenia), dizziness, fatigue, headache, mouth pain, voice disorder, arthralgia, asthenia, limb pain, muscle spasm, dyspnea, cough.
Note this is not a complete list of side effects, only common ones.
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