BLEPHAMIDE (Sulfacetamide/ Prednisolone)

BLEPHAMIDE (Sulfacetamide/ Prednisolone)

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What is this medication?

Sulfacetamide/Prednisolone, Blephamide Liquifilms
Antibiotic, Corticosteroid, Ophthalmic

Indicated for treatment of inflammatory ocular conditions.

How does this medication work?

Blephamide interferes with bacterial growth by inhibiting bacterial growth by inhibiting bacterial folic acid synthesis through competitive antagonism of PABA; decreases inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability; suppresses the immune system by reducing activity and volume of the lymphatic system. 

How should I take this medication?

Usual (Ophthalmic):
Ointment: Apply ~1/2 inch ribbon to lower conjunctival sac 3 to 4 times daily and at bedtime.

Solution: Instill 2 drops every 4 hours to the affected eye.

Suspension: Instill 2 drops every 4 hours during the day and at bedtime to the affected eye.

How to Use:  For ophthalmic use only.  Avoid contamination, do not touch container tip to eyelids or other surfaces when placing drops or ointment in eyes. Do not apply with silver preparations. Discontinue if symptoms do not improve after 2 days.  

What should I watch for while using this medication?

Before starting Sulfacetamide/Prednisolone, Blephamide Liquifilms make sure your physician is aware of any allergies or medications you currently take, and activities you perform. Sulfacetamide/Prednisolone, Blephamide Liquifilms has been associated with severe reactions including agranulocytosis, aplastic anemia and other blood dyscrasias. Sulfacetamide/Prednisolone, Blephamide Liquifilms can also cause severe skin reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis.  Prolonged use of steroids may result in posterior subcapsular cataract formation and may increase intraocular pressure, resulting in ocular hypertension/glaucoma with damage to the optic nerve, defects in visual acuity, and fields of vision. Acute anterior uveitis may occur in susceptible patients, primarily black patients. Use with caution in patients with glaucoma (steroids increase intraocular pressure).  Perforation may occur with topical steroids in diseases which thin the cornea or sclera. Intraocular pressure should be monitored if this product is used >10 days. Sulfacetamide/Prednisolone, Blephamide Liquifilms should be used with caution in patients with severe dry eye.

What if I miss a dose?

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use two doses at one time.

How should I store this medication?

BLEPHAMIDE® should be stored at 15º to 25ºC. Protect from freezing and light. Store in an upright position. Sulfonamide solutions, on long standing and exposure to heat and light, will darken in color and should be discarded if they become dark brown. Yellowing does not affect activity. Keep out of reach of children.

What are the possible side effects of using this medication?

The frequency and incidence of side effects is not well defined but do include:

Agranulocytosis, aplastic anemia, fulminant hepatic necrosis, hypersensitivity reaction, secondary infection, blepharoptosis, eye perforation, glaucoma, increased intraocular pressure, mydriasis, wound healing impairment.