What is this medication?
Anti-Parkinson Agent, MAO Type B Inhibitor
Rasagiline, Azilect is indicated for treat symptoms of parkinsons disease.
How does this medication work?
Rasagiline, Azilect is a potent, irreversible and selective inhibitor of monoamine oxidase (MAO) type B in the central nervous system, which plays a major role in the catabolism of dopamine and other neurotransmitters. Inhibition of dopamine depletion in the striatal region of the brain reduces the symptomatic motor deficits of Parkinson’s disease.
How should I take this medication?
Oral: 0.5-1mg once daily. When added to existing levodopa therapy, a dose reduction of levodopa may be required to avoid exacerbation of dyskinesias.
How to Take: Follow instructions provided by physician/pharmacy label, take consistently at same time each day unless otherwise directed.
You Need to Avoid: Alcohol may increase toxic effects of MAO inhibitor and should be avoided. Concurrent ingestion of foods rich in tyramine, dopamine, tyrosine, phenylalanine, tryptophan, or caffeine may cause sudden and severe high blood pressure (hypertensive crisis or serotonin syndrome).
What should I watch for while using this medication?
Before starting Rasagiline, Azilect make sure your physician is aware of any allergies, medications you currently take, if you have liver disease, or a psychotic disorder. Rasagiline use has been associated with rare but serious adverse events such as CNS effects, dyskinesia, impulse control disorder, hypertension, melanoma, orthostatic hypotension, serotonin syndrome, and somnolence. Rasaligine has many drug interactions, so discuss any supplements, natural health products, or nonprescription medications with your prescriber/pharmacist prior to using.
Avoid foods containing high amounts (>150 mg) of tyramine (aged or matured cheese, air-dried or cured meats including sausages and salamis; fava or broad bean pods, tap/draft beers, Marmite concentrate, sauerkraut, soy sauce, and other soybean condiments). Food’s freshness is also an important concern; improperly stored or spoiled food can create an environment in which tyramine concentrations may increase. Avoid these foods during and for 2 weeks after discontinuation of medication.
Antiparkinsonian discontinuation syndrome:
Abrupt discontinuation or interruption of antiparkinsonian therapy has been associated with a discontinuation syndrome, which may resemble neuroleptic malignant syndrome; symptoms may include elevated temperature, muscular rigidity, altered consciousness, and autonomic instability.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Headache, dyspepsia, depression, increased risk of falls, arthralgia
Note this is not a complete list of side effects, only common ones.
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