ATRIPLA (Efavirenz/Emtricitabine/ Tenofovir)

ATRIPLA (Efavirenz/Emtricitabine/ Tenofovir)

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What is this medication?

Efavirenz+Emtricitabine+Tenofovir, Atripla
Antiretroviral, Reverse Transcriptase Inhibitor

Efavirenz+Emtricitabine+Tenofovir, Atripla is indicated for treatment of HIV-1 Infection.

“Alert: Black Box Warning

Post-Treatment Acute Exacerbation of Hepatitis B
Severe, acute exacerbations of hepatitis B virus (HBV) have been reported in patients who are co-infected with HIV-1 and HBV and have discontinued products containing emtricitabine and/or tenofovir disoproxil fumarate. Closely monitor hepatic function with both clinical and laboratory follow-up for at least several months in patients who are coinfected with HIV-1 and HBV and discontinue efavirenz/emtricitabine/tenofovir disoproxil fumarate. If appropriate, initiation of anti-hepatitis B therapy may be warranted.”

How does this medication work? 

Efavirenz is a non-nucleoside reverse transcriptase inhibitor of HIV-1. It consequently blocks the RNA-dependent and DNA-dependent DNA polymerase activities including HIV-1 replication.  Emtricitabine is a nucleoside reverse transcriptase inhibitor; cytosine analogue that is phosphorylated intracellularly to emtricitabine 5′-triphosphate which interferes with HIV viral RNA dependent DNA polymerase resulting in inhibition of viral replication.

Tenofovir disoproxil fumarate is a nucleotide reverse transcriptase inhibitor; analog of adenosine 5′-monophosphate that interferes with the HIV viral RNA dependent DNA polymerase resulting in inhibition of viral replication. TDF is first converted intracellularly by hydrolysis to tenofovir and subsequently phosphorylated to the active tenofovir diphosphate. Tenofovir inhibits replication of HBV by inhibiting HBV polymerase.

How should I take this medication? 

Oral: Take 1 tablets once daily.

How to Take:
Take on an empty stomach at bedtime to reduce the impact of CNS symptoms.

What should I watch for while using this medication? 

Before starting Efavirenz+Emtricitabine+Tenofovir, Atripla make sure your physician is aware of any allergies or medications you currently take.  Efavirenz+Emtricitabine+Tenofovir, Atripla can cause central nervous system symptoms such as insomnia, abnormal dreams and hallucinations along with impaired concentration, dizziness and drowsiness. Efavirenz+Emtricitabine+Tenofovir, Atripla has been associated with a decrease in bone mineral density, fat redistribution, hepatotoxicity, osteomalacia with renal dysfunction, psychiatric effects, QT prolongation, hepatic and/or renal toxicity and seizures.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Abnormal dreams, hypercholesterolemia, depression, fatigue, dizziness, headache, anxiety, insomnia, skin rash, diarrhea, nausea, vomiting, hematuria, elevated liver enzymes, sinusitis, upper respiratory tract infection, nasopharyngitis.

Note this is not a complete list of side effects, only common ones.