What is this medication?
How does this medication work?
Atovaquone is a selective inhibitor of parasite mitochondrial electron transport. Proguanil hydrochloride primarily exerts its effect by means of the metabolite cycloguanil, a dihydrofolate reductase inhibitor. Inhibition of dihydrofolate reductase in the malaria parasite disrupts deoxythymidylate synthesis. Together, atovaquone/cycloguanil affect the erythrocytic and exoerythrocytic stages of development.
How should I take this medication?
Oral (Prophylaxis): Take 1 tablet (atovaquone 250 mg/proguanil 100 mg per tablet) once daily; start 1 to 2 days prior to entering a malaria-endemic area, continue throughout the stay and for 7 days after returning.
Oral (Treatment): Take 4 tablets (atovaquone 250 mg/proguanil 100 mg per tablet) once daily for 3 days. If used for severe malaria (after completion of IV therapy), use full 3-day schedule (CDC 2020).
How to Take: Take with food at the same time each day. If vomiting occurs within 1 hour of administration, repeat the dose.
What should I watch for while using this medication?
Before starting Atovaquone and Proguanil, Malarone make sure your physician is aware of any allergies or medications you currently take. Elevated liver enzymes have been reported with prophylactic use of Atovaquone and Proguanil, Malarone.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Diarrhea, anorexia, abdominal pain, nausea, vomiting, elevated liver enzymes, pruritis, weakness.
Note this is not a complete list of side effects, only common ones.
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