What is this medication?
Antiplatelet Agent; Phosphodiesterase-3 Enzyme Inhibitor
Anagrelide, Agrylin is indicated for treatment of essential thrombocythemia.
How does this medication work?
Anagrelide, Agrylin Anagrelide causes a dosage-dependant reduction in platelets from decreasing megakaryocyte hypermaturation. It also inhibits cyclic nucleotide phosphodiesterase and the release of arachidonic acid from phospholipase, possibly by inhibiting phospholipase A2.
How should I take this medication?
Oral: Initial: 0.5 mg 4 times daily or 1 mg twice daily and adjust to a platelet count <600,000/mm3 (ideally 150,000/mm3 – 400,000/mm3; usual dose ranges of 1.5 to 3 mg per day).
Maximum single dose: 2.5 mg; maximum daily dose: 10 mg
How to Take: Follow instructions provided by physician/pharmacy label, take consistently at same times each day unless otherwise directed. May be administered without regard to food.
You Need to Avoid: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance so avoid starting any new medications without consulting prescriber. The dose must not be increased by >0.5 mg per day in any one week.
What should I watch for while using this medication?
Before starting Anagrelide, Agrylin make sure your physician is aware of any allergies or medications you currently take, if you have hepatic impairment, are pregnant, or breastfeeding. Anagrelide, Agrylin use has been associated with rare but serious adverse events such as increased risk of major hemorrhagic event, cardiac conductivity disturbances, pulmonary hypertension, pulmonary toxicity, and renal abnormalities.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Edema, palpitations, abdominal pain, diarrhea, nausea, dizziness, headache, pain, asthenia
Note this is not a complete list of side effects, only the most common
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