What is this medication?
Ampicillin is indicated for treatment of GI infections, and respiratory tract infections.
How does this medication work?
Ampicillin inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs) which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.
How should I take this medication?
For oral therapy, including oral step-down therapy after IV ampicillin, oral amoxicillin is usually preferred over oral ampicillin due to improved bioavailability and absorption (bioavailability 77% versus 39% to 54%, respectively). For ease of outpatient IV ampicillin administration, the total daily dose may be administered as a 24-hour continuous infusion.
How to Take: Follow instructions provided by physician/pharmacy label, swallow whole, take consistently at same times each day unless otherwise directed, store at room temperature
What should I watch for while using this medication?
Before starting Ampicillin make sure your physician is aware of any allergies or medications you currently take. You may experience a rash which should be carefully assessed by your doctor. Prolonged usage of antibiotics has resulted in fungal and/or bacterial superinfections including Clostridiodes difficile-associated diarrhea and pseudomembranous colitis.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
The frequency of adverse effects has not been well defined but has been reported to include the following: glossalgia, seizure, sore throat, exfoliative dermatitis, skin rash, urticaria, diarrhea, enterocolitis, candidiasis, stomatitis, vomiting, hematologic changes, elevated liver enzymes, stridor, fever.
Note this is not a complete list of side effects for Ampicillin only common ones.
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