AMERGE (Naratriptan)

What is this medication? 

Naratriptan, Amerge 
Antimigraine; Serotonin 5-HT1B/1D Receptor Agonist

Naratriptan, Amerge is officially indicated to treat acute migraines with or without aura.  It is also used off-label for prevention of menstrual migraines.

How does this medication work? 

Naratriptan, Amerge is a selective agonist for serotonin 5-HT1B and 5-HT1D receptors.  These are located on intracranial blood vessels and sensory nerves of the trigeminal system and activating these receptors causes vasoconstriction and reduces neurogenic inflammation associated with antidromic neuronal transmission.  These actions are thought to be the cause of migraine relief.

How should I take this medication? 

What should I watch for while using this medication? 

Before starting Naratriptan, Amerge make sure your physician is aware of any allergies or medications you currently take (MAO inhibitors/ergotamine derivatives), if you have any cardiovascular disease, cerebrovascular disease, liver disease, kidney disease, a history of hemiplegic migraine, ophthalmoplegic migraine, are pregnant, or breastfeeding.  This medication has risk of causing serotonin syndrome especially if combined with other serotonergic drugs.  Before triptans are used a full cardiac workup including ECG may be considered.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication? 

Headache, nausea, dizziness, drowsiness, fatigue, tingling sensation

Note this is not a complete list of side effects, only common ones.