What is this medication?
Liposomal Amphotericin B, AmBisome
Antifungal Agent, Parenteral
Indicated for treatment of cryptococcal meningitis in patients with HIV, fungal infections.
How does this medication work?
Liposomal Amphotericin B, AmBisome binds to ergosterol altering cell membrane permeability in susceptible fungi and causing leakage of cell components with subsequent cell death. It is believed that AmBisome also causes an oxidation-dependent stimulation of macrophages.
How should I take this medication?
Usual (IV): 3 to 6 mg/kg/day
How to Take: For patients who experience non-anaphylactic immediate infusion-related reactions, premedicate with the following drugs 30 to 60 minutes prior to drug administration: A nonsteroidal anti-inflammatory agent ± diphenhydramine; or acetaminophen with diphenhydramine; or hydrocortisone. If the patient experiences rigors during the infusion, meperidine may be administered.
What should I watch for while using this medication?
Before using Liposomal Amphotericin B, AmBisome, make sure your physician is aware of any allergies or medications you currently take, pre-existing medical conditions and activities you perform. Acute infusion reactions (including fever and chills) may occur 1 to 3 hours after starting an intravenous infusion. These reactions are usually more common with the first few doses and generally diminish with subsequent doses. Infusion has been rarely associated with hypotension, bronchospasm, arrhythmias, and shock. Liposomal Amphotericin B, AmBisome has been found to be a direct cause of myocardial toxicity.
What if I miss a dose?
This drug needs to be given on a regular schedule. Missed doses may cause your fungal infection to come back or worsen. Amphotericin B, AmBisome will likely be given at the clinic by an experienced nurse. If you have missed an appointment, call your clinic immediately to rebook an appointment to receive your dose as soon as possible.
How should I store this medication?
Unopened vials of lyophilized material are to be stored at temperatures up to 25°C (77°F).
The reconstituted product concentrate may be stored for up to 24 hours at 2°-8°C (36°-46°F) following reconstitution with Sterile Water for Injection, USP. Do not freeze.
What are the possible side effects of using this medication?
Hypertension, tachycardia, peripheral edema, edema, hypotension, chest pain, localized phlebitis, chills, insomnia, headache, pain, anxiety, confusion, skin rash, pruritus, hypokalemia, hypomagnesemia, hyperglycemia, hypocalcemia, hyponatremia, hypervolemia, nausea, vomiting, diarrhea, abdominal pain, constipation, anorexia, nephrotoxicity, hematuria, anemia, leukopenia, thrombocytopenia, increased serum alkaline phosphatase, hyperbilirubinemia, increased serum ALT, increased serum AST, abnormal hepatic function tests, transfusion reaction, sepsis, infection, weakness, back pain, increased serum creatinine, increased blood urea nitrogen, dyspnea, pulmonary disease, cough, epistaxis, pleural effusion, rhinitis, infusion related reactions, chills, vomiting, nausea, dyspnea, tachycardia, hypertension, vasodilation, hypotension
Note this is not a complete list of side effects, only the most common.
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