What is this medication?
Antiemetic; Selective 5-HT3 Receptor Antagonist
Indicated for treatment of chemotherapy-induced nausea and vomiting; postoperative nausea and vomiting.
How does this medication work?
Palonosetron, Aloxi is a selective 5-HT3 receptor antagonist, which blocks serotonin, both on vagal nerve terminals in the periphery and centrally in the chemoreceptor trigger zone. Palonosetron inhibits the crosstalk between the 5-HT3 and NK1 receptors.
How should I take this medication?
IV: 0.25 mg as a single dose beginning ~30 minutes prior to the start of chemotherapy.
Capsule [Canadian product]:
Oral: 0.5 mg ~1 hour prior to the start of chemotherapy.
IV: 0.075 mg as a single dose immediately prior to anesthesia induction.
How to Take: Administer capsule ~1 hour prior to the start of chemotherapy. May be administered with or without food. For IV use, Flush IV line with normal saline prior to and following palonosetron administration. Do not mix with other medications. For the prevention of chemotherapy-induced nausea and vomiting infuse over 30 seconds, beginning ~30 minutes prior to the start of chemotherapy. For the prevention of postoperative nausea and vomiting infuse over 10 seconds
immediately prior to anesthesia induction.
What should I watch for while using this medication?
Before starting Palonosetron, Aloxi make sure your physician is aware of any allergies or medications you currently take, if you are pregnant, or breastfeeding. Palonosetron, Aloxi use has been associated with rare but serious adverse events such as hypersensitivity reactions, serotonin syndrome, and ECG changes.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Pruritis, hyperkalemia, constipation, diarrhea, flatulence, urinary retention, headache, bradycardia, hypotension
Note this is not a complete list of side effect, only the most common.
- Choosing a selection results in a full page refresh.
- Press the space key then arrow keys to make a selection.