What is this medication?
Brand Name US: Alecensa
Canadian Equivalent: Alecensaro
Metastatic non-small cell lung cancer
How does this medication work?
Alectinib, Alecensa/Alecensaro is a tyrosine kinase inhibitor that blocks the activity of anaplastic lymphoma kinase (ALK) on cancer cells. Alectinib’s inhibition of ALK slows down and/or stops the growth of tumors
How should I take this medication?
Usual (Oral): 600mg twice daily; continue until disease progression or unacceptable toxicity.
Note: If a dose is missed or if vomiting occurs, administer the next dose at the regularly scheduled time.
How to Take: Take with food. Swallow the capsule whole; do not open or dissolve the contents of the capsule. If vomiting occurs after taking the dose, do not administer an extra dose.
Note: Avoid sun exposure during treatment and for up to 7 days after the final Alectinib dose). Make sure to use a broad spectrum sunscreen and lip balm (SPF ≥50).
What should I watch for while using this medication?
Before starting Alectinib, Alecensa/Alecensaro make sure your physician is aware of any allergies or medications you currently take, and current medical conditions. Alectinib can cause bradycardia, hepatotoxicity, myalgia, pulmonary toxicity in the form of severe interstitial lung disease (ILD), and renal toxicity all of which may require therapy interruption and/or dose reduction. Alectinib, Alecensa/Alecensaro should only be considered for patients who have been tested for the presence of abnormal ALK positivity in tumor tissue or plasma specimens.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Cardiovascular: Edema (30%), bradycardia (8% to 18%)
Central nervous system: Fatigue (≤41%), headache (17%)
Dermatologic: Skin rash (18%)
Endocrine & metabolic: Hyperglycemia (36%), hypocalcemia (32%), hypokalemia (29%), hypophosphatemia (21%), hyponatremia (20%), weight gain (11%)
Gastrointestinal: Constipation (34%), nausea (18%), diarrhea (16%), vomiting (12%)
Hematologic & oncologic: Anemia (56%, grades 3/4: 2%), lymphocytopenia (22%, grades 3/4: 5%)
Hepatic: Increased serum AST (51%), increased serum alkaline phosphatase (47%), hyperbilirubinemia (39%), increased serum ALT (34%)
Neuromuscular & skeletal: Increased creatine phosphokinase (43%), weakness (≤41%), musculoskeletal pain (≤29%), myalgia (≤29%), back pain (12%)
Renal: Increased serum creatinine (28%)
Respiratory: Cough (19%), dyspnea (16%)
1% to 10%:
Cardiovascular: Pulmonary embolism (1%)
Dermatologic: Skin photosensitivity (10%)
Ophthalmic: Visual disturbances (10%)
Renal: Renal insufficiency (8%)
<1%, postmarketing, and/or case reports: Interstitial pulmonary disease, pneumonitis
Note this is not a complete list of side effects, only the most common.
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