What is this medication?
Potassium Sparing Diuretic; Mineralocorticoid (Aldosterone) Receptor Antagonist
Spironolactone, Aldactone is officially indicated for ascites (fluid buildup in abdomen from liver cirrhosis), heart failure with reduced ejection fraction, hypertension (high blood pressure), or primary aldosteronism. It is also commonly prescribed off-label for acne vulgaris in women, heart failure with preserved ejection fraction, hirsutism in women (excessive body hair), hormone therapy for transgender females (male to female). (may be used for conditions not listed)
How does this medication work?
Spironolactone, Aldactone competitively inhibits aldosterone receptors on distal tubule of nephron (functional unit of the kidney) resulting in increased sodium, chloride, and water excretion whilst preserving potassium and hydrogen ions. May block the effects of aldosterone on arteriole smooth muscle. Has some antiandrogen (testosterone) activity and some estrogen activity.
How should I take this medication?
Oral: 12.5-400 mg daily depending on condition divided into one or two daily doses
How to Take: Follow instructions provided by physician/pharmacy label, take consistently at same times each day unless otherwise directed, store at room temperature , ideally taken early in the day to avoid nocturia (waking up to urinate). Take with or without food but be consistent to minimize fluctuations in drug exposure as food increases absorption.
You Need to Avoid: Do not skip follow up appointments or put off bloodwork requisitioned by your physician. Serious electrolyte disturbances may occur without proper monitoring.
What should I watch for while using this medication?
Before starting Spironolactone, Aldactone make sure your physician is aware of any allergies, medications you currently take, if you have liver disease, kidney disease, or are pregnant or breastfeeding. This medication if given in excessive doses can result in significant diuresis which can lead to fluid and electrolyte depletion so patients must be monitored closely.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Gynecomastia (growth of breast tissue in men), hair loss, orthostatic hypotension, urinary frequency, dizziness, nausea, vomiting, muscle cramps, electrolyte disturbances, photosensitivity, stomach upset
Note this is not a complete list of side effects.
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