What is this medication?
Antidiabetic Agent, Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist
Indicated for management of Diabetes, Type 2
How does this medication work?
Lixisenatide, Adlyxin is a selective glucagon-like peptide-1 (GLP-1) receptor agonist. Acting on the same receptor as the endogenous hormone incretin, lixisenatide increases glucose-dependent insulin secretion, decreases inappropriate glucagon secretion, and slows gastric emptying.
How should I take this medication?
Usual (SubQ): Initial 10mcg once daily for 14 days; on days 15 increase to a maintenance dose of 20mcg once daily.
Note: Due to lack of additive glycemic benefit, avoid concomitant use with a dipeptidyl peptidase-4 inhibitor. May require a dose reduction of insulin and/or insulin secretagogues (sulfonylureas, meglitinides) to avoid hypoglycemia.
How to Take: Administer subcutaneously in the abdomen, thigh, or upper arm. Rotate injection sites for each dose; do not use the same site for each injection. Administer within one hour before the first meal of the day, preferably the same meal each day. Solution should appear clear and colorless; do not use if particulate matter or coloration is seen. For each new prefilled pen, activate the device before the first injection by attaching a pen needle, pulling the injection button out, and then injecting into the air or a container (continue to depress the button until it stops and for an additional 2 seconds); these activation steps should not be performed for subsequent injections. Use a new needle for each injection. Once injected, continue to depress the button until it stops and for an additional 2 seconds. Then, remove the needle.
What should I watch for while using this medication?
Before using Lixisenatide, Adlyxin make sure your physician is aware of any allergies or medications you currently take, pre-existing medical conditions and activities you perform. Lixisenatide, Adlyxin may be associated with the development of anti-lixisenatide antibodies, higher risk of gallbladder and bile duct disease, including cholelithiasis and cholecystitis. Lixisenatide, Adlyxin has been reported to cause acute pancreatitis and should be monitored closely for signs and symptoms of pancreatitis (eg, persistent severe abdominal pain which may radiate to the back, and which may or may not be accompanied by vomiting). Lixisenatide, Adlyxin slows down gastric emptying and is not recommended for use in patients with gastroparesis. Lixisenatide, Adlyxin should be used with caution in patients with mild to moderate renal impairment.
What if I miss a dose?
If dose is missed, administer within one hour of next meal.
How should I store this medication?
Keep out of the reach of children at all times. Store in the refrigerator at 36°-46°F (2°C-8°C). Do not freeze. Keep the prefilled pen in the original package to protect it from light. After first use, store below 86°F (30°C). Replace the pen cap after each use to protect from light. Discard pen 14 days after first use.
What are the possible side effects of using this medication?
Gastrointestinal symptoms, antibody development, headache, dizziness, vomiting, diarrhea, constipation, dyspepsia, abdominal distension, upper abdominal pain, injection site reaction.
Note this is not a complete list of side effects, only the most common.
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