What is this medication?
Amphotericin B Lipid Complex, Abelcet
Indicated for treatment of fungal infections.
How does this medication work?
Amphotericin B Lipid Complex, Abelcet binds to ergosterol altering cell membrane permeability in susceptible fungi and causing leakage of cell components with subsequent cell death. It is believed that Abelcet causes an oxidation-dependent stimulation of macrophages.
How should I take this medication?
Usual (IV): 5 mg/kg once daily
How to Take:
IV: Premedicate 30-60 minutes prior to drug administration with a nonsteroidal anti-inflammatory agent ± diphenhydramine or acetaminophen with diphenhydramine or hydrocortisone. Pre-infusion administration of 500 to 1,000 mL of NS appears to reduce the risk of nephrotoxicity during Abelcet treatment.
If the patient experiences rigor during the infusion, meperidine may be administered. Administer at an infusion rate of 2.5 mg/kg/hour. Invert infusion container several times prior to administration and every 2 hours during infusion if it exceeds 2 hours. Do not use an in-line filter during administration. Flush line with dextrose; normal saline may cause precipitate.
What should I watch for while using this medication?
Before using Amphotericin B Lipid Complex, Abelcet, make sure your physician is aware of any allergies or medications you currently take, pre-existing medical conditions and activities you perform. Acute infusion reactions (including fever and chills) may occur 1-2 hours after starting an intravenous infusion. These reactions are usually more common with the first few doses and generally diminish with subsequent doses. Infusion has been rarely associated with hypotension, bronchospasm, arrhythmias, and shock. Abelcet has been found to be a direct cause of myocardial toxicity.
What if I miss a dose?
If Abelcet, amphotericin B lipid complex is given while you are in the hospital, you are not likely to miss a dose.
If you are receiving this medicine in an outpatient clinic, call your doctor as soon as possible for instructions if you miss an appointment for your dose.
How should I store this medication?
Keep out of the reach of children at all times. Prior to admixture, store at 2º to 8ºC (36º to 46ºF), protected from exposure to light. Do not freeze. Keep in the carton until time of use. The admixed Abelcet and 5% Dextrose Injection may be stored for up to 48 hours at 2º to 8ºC (36º to 46ºF) and an additional 6 hours at room temperature. Do not freeze. Any unused material should be discarded.
What are the possible side effects of using this medication?
Chills, increased serum creatinine, fever, multi-organ failure, hypotension, cardiac arrest, hypertension, chest pain, headache, pain, skin rash, hypokalemia, nausea, vomiting, diarrhea, abdominal pain, gastrointestinal hemorrhage, thrombocytopenia, anemia, leukopenia, hyperbilirubinemia, sepsis, infection, renal failure, respiratory failure, dyspnea, respiratory tract disease
Note this is not a complete list of side effects, only the most common.
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